Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. The SportsLine Projection Model simulates every FBS college football game 10,000 times. Notre Dame picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model. Clemson odds list the Irish as 3.5-point favorites, according to the SportsLine consensus, and the over/under for total points scored is set at 43.5. The latest SportsLine consensus Notre Dame vs. Saturday's kickoff is set for noon ET at Memorial Stadium in Clemson, S.C. Clemson won both games, but the Irish beat the Tigers 35-14 in South Bend last year. These teams faced off in the 2018 Cotton Bowl national semifinal, as well as the 2020 ACC title game. 4 Florida State to overtime earlier in the season. The Tigers (4-4, 2-4 ACC) have lost two in a row but pushed No. The Irish (7-2) have lost to two ranked teams but come in off consecutive victories. The 15th-ranked Notre Dame Fighting Irish could encounter a tricky test when they visit Death Valley on Saturday to face the Clemson Tigers in a college football Week 10 matchup.
